The cast includes Bob Barrett as Doctor Armstrong, who is well known for his role as Dr Sacha Levy in the BBC's 'Holby City'.
Also starring in the show is Joseph Beattie (Hex and Silent Witness) as Philip Lombard and Oliver Clayton (The Play That Goes Wrong) as Anthony Marston.
And Then There Were None is the best-selling crime novel of all time, and has sold over a 100 million copies worldwide since its first publication in 1939.
The classic story has been reinvented for the 21st century in this brand-new production, directed by Lucy Bailey.
The rest of the cast includes: Jeffery Kissoon as General Mackenzie, Andrew Lancel as William Blore, Nicola May-Taylor as Jane Pinchbeck, Louise McNulty as Understudy, Katy Stephens as Emily Brent, Lucy Tregear as Georgina Rogers, Sophie Walter as Vera Claythorne, Matt Weyland as Narracott/Understudy, and David Yelland as Judge Wargrave.
Tickets start from £13 and are available via the Grand Opera House website.