The union, which largely represents train drivers, has called multiple strikes on different days at train operators across the country.
As such, Northern customers connecting onto services with other train operators are advised to check before they travel for all journeys between Monday 6 and Saturday 11 May.
During that period (6-11 May), Northern says its services are likely to be busier than usual as people take alternative routes to avoid strikes elsewhere.
For more information about the strike, visit: www.northernrailway.co.uk/travel/strikes.
Tricia Williams, chief operating officer for Northern, said: “Unfortunately, the action by ASLEF on Thursday 9 May will see our network grind to a halt.
“On the days when strikes are taking place with other train operators, we will do everything we can to keep our services moving and absorb those extra passengers trying to travel across the region.
“We can only apologise, once again, for the disruption this action by ASLEF will cause to people in the North of England.”
Northern is the second largest train operator in the UK, with 2,500 services a day to more than 500 stations across the North of England.
A new initiative to boost retail in York launches this Winter
York Christmas Walking Tour Guide selected for presentation to Chairman of Visit England
Hop on board York's magical Christmas bus
Transdev's electric transormation wins UK national award
International Men’s Day: Train operator reveals why it put the men who make up 80% of its workforce at the heart of its EDI strategy